Search results for "Local factor"
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Osteonecrosis of the jaws associated with denosumab : study of clinical and radiographic characteristics in a series of clinical cases
2020
Background The objective of this study was to describe the clinical and radiographic characteristics of our series of medication-related osteonecrosis of the jaws (ONJ) associated with denosumab. Material and methods We presented 15 cases of ONJ associated with denosumab; 11 received treatment for their osteoporosis and four for cancer treatments. We recorded the most frequent clinical findings, symptoms and radiographic characteristics in our patient group, as well as local and systemic contributing factors. Results The mean time of treatment with denosumab was 23.83 ± 12.84 months. 40% of the patients had a previous history of treatment with bisphosphonates. The most common local factor w…
La guarigione della ferita chirurgica nel cavo orale
2021
OBJECTIVES The aim of the study is to describe the physiological mechanism of healing of the surgical wound of the oral cavity and to present the systemic and local factors that can influence it. MATERIALS AND METHODS Hemostasis starts with the activation of the platelets and the coagulation cascade which carry out the vascular constriction and the formation of the fibrin clot which stops the blood loss and provides a temporary scaffold for the migration and anchoring of the cells that will reach the subsequent stages. The clot and surrounding injured tissue begin to release pro-inflammatory cytokines and growth factors such as tranforming growth factor-β (TGF-β), platelet-derived growth fa…